Alterations of hand sensorimotor function and cortical motor representations over the adult lifespan.

ABSTRACT: Using a cross sectional design, we aimed to identify the effect of aging on sensorimotor function and cortical motor representations of two intrinsic hand muscles, as well as the course and timing of those changes. Furthermore, the link between cortical motor representations, sensorimotor function, and intracortical inhibition and facilitation was investigated. Seventy-seven participants over the full adult lifespan were enrolled. For the first dorsal interosseus (FDI) and abductor digiti minimi (ADM) muscle, cortical motor representations, GABA_A-mediated short-interval intracortical inhibition (SICI), and glutamate-mediated intracortical facilitation (ICF) were assessed using transcranial magnetic stimulation over the dominant primary motor cortex. Additionally, participants' d

SUBMITTER: Hehl M 

PROVIDER: S-EPMC7093194 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature