Striatal Dopamine Responses to Feeding are Altered in People with Obesity.

ABSTRACT:

Objective

This study determined whether striatal dopamine (DA) release is affected by food ingestion and whether the DA response to high-calorie food images is greater in the fasted than in the fed state in people with obesity.

Methods

Striatal DA release was evaluated in 10 people with obesity and prediabetes after consuming a meal to satiation and after fasting overnight as well as in response to viewing images of high-calorie compared with low-calorie foods after consuming a meal to satiation or fasting overnight by using positron emission tomography with [¹¹ C]raclopride injection.

Results

Striatal DA D2/D3 receptor availability was not different during fasted and fed conditions. Viewing images of high-calorie foods induced striatal DA release relative

SUBMITTER: Eisenstein SA 

PROVIDER: S-EPMC7093218 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature