Measures of Adipose Tissue Redistribution and Atherosclerotic Coronary Plaque in HIV.

ABSTRACT:

Objective

People with HIV (PWH) who are well treated on antiretroviral therapy remain at increased risk for body composition changes, including increased visceral adipose tissue (VAT) and reduced subcutaneous adipose tissue (SAT), as well as increased cardiovascular disease (CVD). The relationship between adipose compartments and coronary disease is not well understood among PWH.

Methods

A total of 148 PWH and 68 uninfected individuals without CVD were well phenotyped for VAT and SAT via single-section abdominal computed tomography (CT) at L4. Coronary artery calcium (CAC) score was assessed by noncontrast cardiac CT and coronary plaque composition by coronary CT angiography.

Results

Increased VAT was significantly related to increased presence of plaque (OR, 1.55 per

SUBMITTER: Bogorodskaya M 

PROVIDER: S-EPMC7093223 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature