Insulin resistance and obesity, and their association with depression in relatively young people: findings from a large UK birth cohort.

ABSTRACT:

Background

Depression frequently co-occurs with disorders of glucose and insulin homeostasis (DGIH) and obesity. Low-grade systemic inflammation and lifestyle factors in childhood may predispose to DGIH, obesity and depression. We aim to investigate the cross-sectional and longitudinal associations among DGIH, obesity and depression, and to examine the effect of demographics, lifestyle factors and antecedent low-grade inflammation on such associations in young people.

Methods

Using the Avon Longitudinal Study of Parents and Children birth cohort, we used regression analyses to examine: (1) cross-sectional and (2) longitudinal associations between measures of DGIH [insulin resistance (IR); impaired glucose tolerance] and body mass index (BMI) at ages 9 and 18 years, and depre

SUBMITTER: Perry BI 

PROVIDER: S-EPMC7093318 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature