The clinical significance of long non-coding RNA ANRIL level in diabetic retinopathy.

ABSTRACT:

Aim

To analyse the expression of lncRNA-ANRIL and other related factors in different human body fluids, explore the clinical significance of ANRIL and validate whether ANRIL is interrelated with the renin-angiotensin system and NF-κB signalling pathway.

Methods

Ninety-one patients were included in this cross-sectional study and were divided into the NDM group (20 patients), DM group (25 patients), NPDR group (21 patients) and PDR group (25 patients). Basic information and samples of serum, aqueous fluid and vitreous fluid were collected before vitrectomy or intravitreal injection. The transcription and levels of ANRIL and other related factors were detected by RT-PCR and ELISA. Statistical Package for Social Sciences software was used for statistical analysis.

Results

SUBMITTER: Chen S 

PROVIDER: S-EPMC7093365 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature