Preparation and characterization of nanoclay-hydrogel composite support-bath for bioprinting of complex structures.

ABSTRACT: Three-dimensional bioprinting of cell-laden hydrogels in a sacrificial support-bath has recently emerged as a potential solution for fabricating complex biological structures. Physical properties of the support-bath strongly influence the bioprinting process and the outcome of the fabricated constructs. In this study, we reported the application of a composite Pluronic-nanoclay support-bath including calcium ions as the crosslinking agent for bioprinting of cell-laden alginate-based hydrogels. By tuning the rheological properties, a shear-thinning composite support-bath with fast self-recovery behavior was yielded, which allowed continuous printing of complex and large-scale structures. The printed structures were easily and efficiently harvested from the support-bath without disturbing th

SUBMITTER: Afghah F 

PROVIDER: S-EPMC7093553 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature