Polymorphisms of BIRC5 Gene is Associated with Chronic HBV Infection in Iranian Population.

ABSTRACT: Survivin can affect the progression of infection and is considered as a marker of various malignancies. The aim of the study was to investigate the possible association of gene polymorphisms of survivin (-1547A/G, -644C/T, -625 C/G, -241C/T, -31G/C, -141G/C) and chronic hepatitis B infection in Iranian patients. The genotypes of survivin SNPs were investigated by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method using 100 chronic HBV infected patients (HBV), 40 spontaneously recovered HBV subjects and 100 healthy controls (C). Serum level of survivin was determined using ELISA method. The -1547G, -625C, -241T and -31C alleles were associated with increased susceptibility to chronic hepa

SUBMITTER: Moudi B 

PROVIDER: S-EPMC7093622 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature