Microcirculatory dysfunction and dead-space ventilation in early ARDS: a hypothesis-generating observational study.

ABSTRACT:

Background

Ventilation/perfusion inequalities impair gas exchange in acute respiratory distress syndrome (ARDS). Although increased dead-space ventilation (V_D/V_T) has been described in ARDS, its mechanism is not clearly understood. We sought to evaluate the relationships between dynamic variations in V_D/V_T and extra-pulmonary microcirculatory blood flow detected at sublingual mucosa hypothesizing that an altered microcirculation, which is a generalized phenomenon during severe inflammatory conditions, could influence ventilation/perfusion mismatching manifested by increases in V_D/V_T fraction during early stages of ARDS.

Methods

Forty-two consecutive patients with early moderate and severe ARDS were included. P

SUBMITTER: Ospina-Tascon GA 

PROVIDER: S-EPMC7093634 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature