RNA-seq data of soleus muscle tissue after spinal cord injury under conditions of inactivity and applied exercise.

ABSTRACT: Reduced muscle mass and increased fatiguability are major complications after spinal cord injury (SCI), and often hinder the rehabilitation efforts of patients. Such detriments to the musculoskeletal system, and the concomitant reduction in level of activity, contribute to secondary complications such as cardiovascular disease, diabetes, bladder dysfunction and liver damage. As a result of decreased weight-bearing capacity after SCI, muscles undergo morphological, metabolic, and contractile changes. Recent studies have shown that exercise after SCI decreases muscle wasting and reduces the burden of secondary complications. Here, we describe RNA sequencing data for detecting chronic transcriptomic changes in the rat soleus after SCI at two levels of injury severity, under conditions of rest

SUBMITTER: Chariker JH 

PROVIDER: S-EPMC7093805 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature