LAMA2 regulates the fate commitment of mesenchymal stem cells via hedgehog signaling.

ABSTRACT:

Background

Bone defects are a common clinical condition that has gained an increasing amount of attention in recent years. Causes of bone defect include tumors, inflammation, and fractures. Bone tissue engineering is a novel treatment of bone defect, and human mesenchymal stem cells (hMSCs) are the ideal seed cells for bone tissue engineering due to their multi-lineage differentiation potential and immunogenicity. The laminin α2 (LAMA2) gene encodes the α2 subunit of laminins. Mutations in this gene have been reported to cause muscular dystrophy, but thus far no studies have elucidated the role of LAMA2 in the fate choices of MSCs. Here, we aimed to investigate the critical role of LAMA2 in the osteogenesis and adipogenesis of mesenchymal stem cells (MSCs).

Methods

We invest

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC7093965 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature