Expression of RSK4, CD44 and MMP-9 is upregulated and positively correlated in metastatic ccRCC.

ABSTRACT:

Background

To investigate the expression and function of RSK4, MMP-9 and CD44 in primary clear cell renal cell carcinoma (primary ccRCC) and metastatic clear cell renal cell carcinoma (metastatic ccRCC), as well as the correlation with clinicopathological features of patients.

Method

The expression levels of RSK4, CD44 and MMP-9 in 52 primary ccRCC samples and 48 metastatic ccRCC samples were detected by immunohistochemistry, and the relationship between RSK4, CD44 and MMP-9 expression and clinicopathological features as well as prognosis of metastatic ccRCC patients was statistically analysed. Ectopic RSK4 expression in ccRCC cell lines was performed to determine its effect on cell cycle regulation, tumour invasiveness, and metastatic capability.

Results

The positive

SUBMITTER: Ma J 

PROVIDER: S-EPMC7093975 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature