Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection.

ABSTRACT:

Introduction

Immunological damage in acute HIV infection (AHI) may predispose to detrimental clinical sequela. However, studies on the earliest HIV-induced immunological changes are limited, particularly in sub-Saharan Africa. We assessed the plasma cytokines kinetics, and their associations with virological and immunological parameters, in a well-characterized AHI cohort where participants were diagnosed before peak viremia.

Methods

Blood cytokine levels were measured using Luminex and ELISA assays pre-infection, during the hyperacute infection phase (before or at peak viremia, 1-11 days after the first detection of viremia), after peak viremia (24-32 days), and during the early chronic phase (77-263 days). Gag-protease-driven replicative capacities of the transmitted/found

SUBMITTER: Muema DM 

PROVIDER: S-EPMC7093991 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature