Superinfection and cell regeneration can lead to chronic viral coinfections.

ABSTRACT: Molecular diagnostic techniques have revealed that approximately 43% of the patients hospitalized with influenza-like illness are infected by more than one viral pathogen, sometimes leading to long-lasting infections. It is not clear how the heterologous viruses interact within the respiratory tract of the infected host to lengthen the duration of what are usually short, self-limiting infections. We develop a mathematical model which allows for single cells to be infected simultaneously with two different respiratory viruses (superinfection) to investigate the possibility of chronic coinfections. We find that a model with superinfection and cell regeneration has a stable chronic coinfection fixed point, while superinfection without cell regeneration produces only acute infections. This ana

SUBMITTER: Pinky L 

PROVIDER: S-EPMC7094138 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature