Sequence comparison via polar coordinates representation and curve tree.

ABSTRACT: Sequence comparison has become one of the essential bioinformatics tools in bioinformatics research, which could serve as evidence of structural and functional conservation, as well as of evolutionary relations among the sequences. Existing graphical representation methods have achieved promising results in sequence comparison, but there are some design challenges with the graphical representations and feature-based measures. We reported here a new method for sequence comparison. It considers whole distribution of dual bases and employs polar coordinates method to map a biological sequence into a closed curve. The curve tree was then constructed to numerically characterize the closed curve of biological sequences, and further compared biological sequences by evaluating the distance of the

SUBMITTER: Dai Q 

PROVIDER: S-EPMC7094155 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature