Acute and Chronic Effects of Betel Quid Chewing on Brain Functional Connectivity.

ABSTRACT:

Background

The active alkaloid in Betel quid is arecoline. Consumption of betel quid is associated with both acute effects and longer-term addictive effects. Despite growing evidence that betel quid use is linked with altered brain function and connectivity, the neurobiology of this psychoactive substance in initial acute chewing, and long-term dependence, is not clear.

Methods

In this observational study, functional magnetic resonance imaging in a resting-state was performed in 24 male betel quid-dependent chewers and 28 male controls prior to and promptly after betel quid chewing. Network-based statistics were employed to determine significant differences in functional connectivity between brain networks for both acute effects and in long-term betel users versus controls.

SUBMITTER: Sariah A 

PROVIDER: S-EPMC7094756 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature