Immune response against Chlamydia trachomatis via toll-like receptors is negatively regulated by SIGIRR.

ABSTRACT: Chlamydia trachomatis is the most common bacterial sexually-transmitted infection and the major cause of preventable blindness worldwide. The asymptomatic nature of many infections along with uncontrolled inflammation leads to irreversible damage in the upper genital tract and the tarsal conjunctivae, with the major complications of infertility and chronic pelvic pain, and blindness, respectively. Inflammation must, therefore, be tightly regulated to avoid an unrestrained immune response. The genetic factors that regulate inflammation through Toll-like receptor (TLR) signaling pathways during C. trachomatis infection have not been fully characterized. SIGIRR (also known as IL-1R8 or TIR8) can regulate inflammation in response to various pathogens and diseases. However, nothing is known abo

SUBMITTER: Al-Kuhlani M 

PROVIDER: S-EPMC7094862 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature