Neuropsychological and psychiatric outcomes in encephalitis: A multi-centre case-control study.

ABSTRACT:

Objectives

Our aim was to compare neuropsychological and psychiatric outcomes across three encephalitis aetiological groups: Herpes simplex virus (HSV), other infections or autoimmune causes (Other), and encephalitis of unknown cause (Unknown).

Methods

Patients recruited from NHS hospitals underwent neuropsychological and psychiatric assessment in the short-term (4 months post-discharge), medium-term (9-12 months after the first assessment), and long-term (>1-year). Healthy control subjects were recruited from the general population and completed the same assessments.

Results

Patients with HSV were most severely impaired on anterograde and retrograde memory tasks. In the short-term, they also showed executive, IQ, and naming deficits, which resolved in the long-term.

SUBMITTER: Harris L 

PROVIDER: S-EPMC7094865 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature