Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.

ABSTRACT: Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health ¹ . Bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (SARS) ^2-10 . Here we provide virological, epidemiological, evolutionary and experimental evidence that a novel HKU2-related bat coronavirus, swine acute diarrhoea syndrome coronavirus (SADS-CoV), is the aetiological agent that was responsible for a large-scale outbreak of fatal disease in pigs in China that has caused the death of 24,693 piglets across four farms. Notably, the out

SUBMITTER: Zhou P 

PROVIDER: S-EPMC7094983 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature