Ontology highlight
ABSTRACT:
SUBMITTER: Wan C
PROVIDER: S-EPMC7096163 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Science advances 20200325 13
Radiotherapy (RT) is routinely used in cancer treatment, but expansion of its clinical indications remains challenging. The mechanism underlying the radiation-induced bystander effect (RIBE) is not understood and not therapeutically exploited. We suggest that the RIBE is predominantly mediated by irradiated tumor cell-released microparticles (RT-MPs), which induce broad antitumor effects and cause immunogenic death mainly through ferroptosis. Using a mouse model of malignant pleural effusion (MP ...[more]