A systematic review and network meta-analysis of adjuvant therapy for curatively resected biliary tract cancers.

ABSTRACT:

Background

Recent randomized controlled trials (rcts) have contributed high-quality data about adjuvant therapy in curatively resected biliary tract cancer (btc); however, a standard approach to treating those patients still has not been developed.

Methods

We conducted a systematic review of published studies and abstracts up to and including June 2018, choosing rcts involving patients with btc receiving adjuvant chemotherapy after complete surgical resection. Network meta-analysis methods were used for indirect comparisons of overall survival (os) and relapse-free survival (rfs) for various adjuvant therapies.

Results

Five rcts were included in qualitative synthesis, and three rcts (bilcap, prodige 12-accord 18, and bcat) had data sufficient for inclusion in the meta

SUBMITTER: Kish M 

PROVIDER: S-EPMC7096209 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature