Risk of second primary papillary thyroid cancer among adult cancer survivors in the United States, 2000-2015.

ABSTRACT:

Background

While radiotherapy is a major risk factor for thyroid cancer after childhood cancer, factors contributing to increased thyroid cancer risk after adulthood cancer remain unclear.

Methods

We evaluated second primary papillary thyroid cancer (PTC) risk among 3,175,216 ≥ 1-year adult survivors of non-thyroid malignancies from US population-based cancer registries (2000-2015), using standardized incidence ratios (SIRs). Because heightened surveillance may increase detection of indolent thyroid tumors and earlier detection of advanced tumors, we examined SIRs by PTC stage and time since first cancer (latency).

Results

SIRs for second primary PTC (N = 4333) were statistically-significantly 1.2-3.5-fold elevated overall and after 23/27 first cancer types evaluated,

SUBMITTER: Schonfeld SJ 

PROVIDER: S-EPMC7096211 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature