First derivative ATR-FTIR spectroscopic method as a green tool for the quantitative determination of diclofenac sodium tablets.

ABSTRACT: Background: Attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy is a rapid quantitative method which has been applied for pharmaceutical analysis. This work describes the utility of first derivative ATR-FTIR spectroscopy in the quantitative determination of diclofenac sodium tablets. Methods: This analytical quantitative technique depends on a first derivative measurement of the area of infrared bands corresponding to the CO stretching range of 1550-1605 cm ^-1. The specificity, linearity, detection limits, precision and accuracy of the calibration curve, the infrared analysis and data manipulation were determined in order to validate the method. The statistical results were compared with other methods for the quantification of diclofenac

SUBMITTER: Fahelelbom KMS 

PROVIDER: S-EPMC7096217 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature