Developmental plasticity allows outside-in immune responses by resident memory T cells.

ABSTRACT: Central memory T (T_CM) cells patrol lymph nodes and perform conventional memory responses on restimulation: proliferation, migration and differentiation into diverse T cell subsets while also self-renewing. Resident memory T (T_RM) cells are parked within single organs, share properties with terminal effectors and contribute to rapid host protection. We observed that reactivated T_RM cells rejoined the circulating pool. Epigenetic analyses revealed that T_RM cells align closely with conventional memory T cell populations, bearing little resemblance to recently activated effectors. Fully differentiated T_RM cells isolated from small intestine epithelium exhibited the potential to differentiate into T_CM cells, effector memory T ce

SUBMITTER: Fonseca R 

PROVIDER: S-EPMC7096285 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature