Efficacy of Posaconazole Prophylaxis for Fungal Disease in Hematology Patients Treated With Chemotherapy and Transplantation: An Open-Label, Prospective, Observational Study.

ABSTRACT:

Background

Posaconazole (PCZ) is used prophylactically to prevent invasive fungal infections (IFIs) in patients with hematological malignancies.

Objective

To evaluate the cut-off serum concentration of PCZ for successful IFI prophylaxis in Chinese subjects.

Patients and methods

A total of 74 patients treated with induction chemotherapy (n = 10) and allogeneic hematopoietic stem cell transplantation (HSCT) (n = 64), who received PCZ prophylactically as an oral suspension for >7 days, were included in the study. Clinical, radiological, microbiological culture results, and treatment responses were analyzed and drug concentration assays performed.

Results

The overall incidence of possible, probable, and proven IFIs was 13.5% (10/74), with five patient

SUBMITTER: Li W 

PROVIDER: S-EPMC7096356 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature