Linear systems analysis for laminar fMRI: Evaluating BOLD amplitude scaling for luminance contrast manipulations.

ABSTRACT: A fundamental assumption of nearly all functional magnetic resonance imaging (fMRI) analyses is that the relationship between local neuronal activity and the blood oxygenation level dependent (BOLD) signal can be described as following linear systems theory. With the advent of ultra-high field (7T and higher) MRI scanners, it has become possible to perform sub-millimeter resolution fMRI in humans. A novel and promising application of sub-millimeter fMRI is measuring responses across cortical depth, i.e. laminar imaging. However, the cortical vasculature and associated directional blood pooling towards the pial surface strongly influence the cortical depth-dependent BOLD signal, particularly for gradient-echo BOLD. This directional pooling may potentially affect BOLD linearity across cortic

SUBMITTER: van Dijk JA 

PROVIDER: S-EPMC7096513 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature