Serum procalcitonin concentrations in dogs with induced endotoxemia.

ABSTRACT:

Background

Procalcitonin (PCT) is an important biomarker for sepsis in human medicine, but there is little information regarding PCT as a biomarker for sepsis in dogs. There are no controlled studies evaluating serial concentrations of PCT in dogs.

Hypothesis/objective

That PCT would be rapidly detectable in serum after injection of LPS and would remain increased for at least 24 hours. Objective was to evaluate serial serum PCT concentrations in dogs after a single IV injection of LPS compared to placebo.

Animals

Six healthy mixed breed dogs.

Methods

A nonrandomized, placebo-controlled, crossover study was performed. Dogs were initially injected with placebo (0.9% NaCl; 1 mL, IV) and then experimental endotoxemia was induced by injecting lipopolysaccharide (LPS

SUBMITTER: Easley F 

PROVIDER: S-EPMC7096631 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature