Paraoxonase-1 activity evaluation as a diagnostic and prognostic marker in horses and foals.

ABSTRACT:

Background

In several species, paraoxonase-1 (PON-1) decreases during inflammation, because of the presence of oxidative stress; its measurement recently has been validated in horses, but its role as a clinical biomarker is unknown.

Objectives

To evaluate sensitivity, specificity and likelihood ratio of PON-1 activity to identify systemic inflammatory response syndrome (SIRS)-positive horses or horses with a poor prognosis.

Animals

One hundred seventy-two blood samples from 58 sick horses from 3 different veterinary hospitals.

Methods

In a cross-sectional study, PON-1 activity was measured upon admission and at 24-hour intervals until discharge or death, and results were analyzed based on SIRS status and outcome.

Results

No statistically significant diff

SUBMITTER: Ruggerone B 

PROVIDER: S-EPMC7096640 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature