Identifying genetic markers of adaptation for surveillance of viral host jumps.

ABSTRACT: Adaptation is often thought to affect the likelihood that a virus will be able to successfully emerge in a new host species. If so, surveillance for genetic markers of adaptation could help to predict the risk of disease emergence. However, adaptation is difficult to distinguish conclusively from the other processes that generate genetic change. In this Review we survey the research on the host jumps of influenza A, severe acute respiratory syndrome-coronavirus, canine parvovirus and Venezuelan equine encephalitis virus to illustrate the insights that can arise from combining genetic surveillance with microbiological experimentation in the context of epidemiological data. We argue that using a multidisciplinary approach for surveillance will provide a better understanding of when adaptatio

SUBMITTER: Pepin KM 

PROVIDER: S-EPMC7097030 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature