Influence of Inspiratory/Expiratory CT Registration on Quantitative Air Trapping.

ABSTRACT: RATIONALE AND OBJECTIVES:The aim of this study was to assess variability in quantitative air trapping (QAT) measurements derived from spatially aligned expiration CT scans. MATERIALS AND METHODS:Sixty-four paired CT examinations, from 16 school-age cystic fibrosis subjects examined at four separate time intervals, were used in this study. For each pair, visually inspected lobe segmentation maps were generated and expiration CT data were registered to the inspiration CT frame. Measurements of QAT, the percentage of voxels on the expiration CT scan below a set threshold were calculated for each lobe and whole-lung from the registered expiration CT and compared to the true values from the unregistered data. RESULTS:A mathematical model, which simulates the effect of variable regions of lung d

SUBMITTER: Weinheimer O 

PROVIDER: S-EPMC7097831 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature