Spatial gene expression analysis of neuroanatomical differences in mouse models.

ABSTRACT: MRI is a powerful modality to detect neuroanatomical differences that result from mutations and treatments. Knowing which genes drive these differences is important in understanding etiology, but candidate genes are often difficult to identify. We tested whether spatial gene expression data from the Allen Brain Institute can be used to inform us about genes that cause neuroanatomical differences. For many single-gene-mutation mouse models, we found that affected neuroanatomy was not strongly associated with the spatial expression of the altered gene and there are specific caveats for each model. However, among models with significant neuroanatomical differences from their wildtype controls, the mutated genes had preferential spatial expression in affected neuroanatomy. In mice exposed to e

SUBMITTER: Fernandes DJ 

PROVIDER: S-EPMC7097887 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature