STAT4: an immunoregulator contributing to diverse human diseases.

ABSTRACT: Signal transducer and activator of transcription 4 (STAT4) is a member of the STAT family and localizes to the cytoplasm. STAT4 is phosphorylated after a variety of cytokines bind to the membrane, and then dimerized STAT4 translocates to the nucleus to regulate gene expression. We reviewed the essential role played by STAT4 in a wide variety of cells and the pathogenesis of diverse human diseases, especially many kinds of autoimmune and inflammatory diseases, via activation by different cytokines through the Janus kinase (JAK)-STAT signaling pathway.

SUBMITTER: Yang C 

PROVIDER: S-EPMC7097918 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature