Physicochemical and Pharmacokinetic Analysis of Anacardic Acid Derivatives.

ABSTRACT: Anacardic acid (AA) and its derivatives are well-known for their therapeutic applications ranging from antitumor, antibacterial, antioxidant, anticancer, and so forth. However, their poor pharmacokinetic and safety properties create significant hurdles in the formulation of the final drug molecule. As a part of our endeavor to enhance the potential and exploration of the anticancer activities, a detailed study on the properties of selected AA derivatives was performed in this work. A comprehensive analysis of the drug-like properties of 100 naturally occurring AA derivatives was performed, and the results were compared with certain marketed anticancer drugs. The work focused on the understanding of the interplay among eight physicochemical properties. The relationships between the physicoc

SUBMITTER: Zafar F 

PROVIDER: S-EPMC7098041 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature