Foundations of modeling in cryobiology-II: Heat and mass transport in bulk and at cell membrane and ice-liquid interfaces.

ABSTRACT: Modeling coupled heat and mass transport in biological systems is critical to the understanding of cryobiology. In Part I of this series we derived the transport equation and presented a general thermodynamic derivation of the critical components needed to use the transport equation in cryobiology. Here we refine to more cryobiologically relevant instances of a double free-boundary problem with multiple species. In particular, we present the derivation of appropriate mass and heat transport constitutive equations for a system consisting of a cell or tissue with a free external boundary, surrounded by liquid media with an encroaching free solidification front. This model consists of two parts-namely, transport in the "bulk phases" away from boundaries, and interfacial transport. Here we der

SUBMITTER: Anderson DM 

PROVIDER: S-EPMC7098062 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature