Identification of berberine as a novel drug for the treatment of multiple myeloma via targeting UHRF1.

ABSTRACT:

Background

Current therapies for multiple myeloma (MM) are associated with toxicity and resistance, highlighting the need for novel effective therapeutics. Berberine (BBR), a botanical alkaloid derived from several Berberis medicinal plants, has exhibited anti-tumor effects, including against multiple myeloma (MM); however, the molecular mechanism underlying the anti-MM effect has not been previously described. This study aimed to identify the target of berberine and related mechanisms involved in its therapeutic activity against MM.

Results

Here, we demonstrated that BBR treatment killed MM cells in vitro and prolonged the survival of mice bearing MM xenografts in vivo. A screening approach integrating surface plasmon resonance (SPR) with liquid chromatography-tandem mass s

SUBMITTER: Gu C 

PROVIDER: S-EPMC7098108 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature