Immune microenvironment in ductal carcinoma in situ: a comparison with invasive carcinoma of the breast.

ABSTRACT:

Background

The immune microenvironment in ductal carcinoma in situ (DCIS) and its significance are not well established. This study was conducted to evaluate the immune microenvironment of DCIS including the composition of tumor-infiltrating lymphocyte (TIL) subsets and PD-L1+ immune cells and to compare it with that of invasive breast cancer.

Materials and methods

A total of 671 cases including three different disease groups of pure DCIS, DCIS with microinvasion (DCIS-M), and invasive carcinoma were included in this study. CD4+, CD8+, and FOXP3+ TIL subsets and PD-L1+ immune cells were detected with immunohistochemistry using tissue microarrays and were analyzed in relation to clinicopathologic characteristics and different disease groups.

Results

In pure DCIS, high

SUBMITTER: Kim M 

PROVIDER: S-EPMC7098119 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature