On estimating the time to statistical cure.

ABSTRACT:

Background

The mortality risk among cancer patients measured from the time of diagnosis is often elevated in comparison to the general population. However, for some cancer types, the patient mortality risk will over time reach the same level as the general population mortality risk. The time point at which the mortality risk reaches the same level as the general population is called the cure point and is of great interest to patients, clinicians, and health care planners. In previous studies, estimation of the cure point has been handled in an ad hoc fashion, often without considerations about margins of clinical relevance.

Methods

We review existing methods for estimating the cure point and discuss new clinically relevant measures for quantifying the mortality difference be

SUBMITTER: Jakobsen LH 

PROVIDER: S-EPMC7098130 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature