DNA methylation outlier burden, health, and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936.

ABSTRACT:

Background

DNA methylation outlier burden has been suggested as a potential marker of biological age. An outlier is typically defined as DNA methylation levels at any one CpG site that are three times beyond the inter-quartile range from the 25th or 75th percentiles compared to the rest of the population. DNA methylation outlier burden (the number of such outlier sites per individual) increases exponentially with age. However, these findings have been observed in small samples.

Results

Here, we showed an association between age and log₁₀-transformed DNA methylation outlier burden in a large cross-sectional cohort, the Generation Scotland Family Health Study (N = 7010, β = 0.0091, p < 2 × 10^-16), and in two longitudinal cohort studies, the Lothian Birth

SUBMITTER: Seeboth A 

PROVIDER: S-EPMC7098133 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature