Sustained exposure to systemic endotoxin triggers chemokine induction in the brain followed by a rapid influx of leukocytes.

ABSTRACT:

Background

Recent years have seen an explosion of research pertaining to biological psychiatry, yet despite subsequent advances in our understanding of neuroimmune communication pathways, how the brain senses and responds to peripheral inflammation remains poorly understood. A better understanding of these pathways may be important for generating novel therapeutics to treat many patients with chronic inflammatory diseases who also suffer from neuropsychiatric comorbidities. Here we have systematically assessed the leukocyte infiltrate to the brain following systemic endotoxin exposure to better understand this novel route of neuroimmune communication.

Methods

Mice were injected intraperitoneally with LPS daily for 2, 5 or 7 consecutive days. We systematically interrogated th

SUBMITTER: Thomson CA 

PROVIDER: S-EPMC7098135 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature