Prognosis of PD-L1 in human breast cancer: protocol for a systematic review and meta-analysis.

ABSTRACT:

Background

Breast cancer is one of the most common malignancies in women worldwide, and one of the leading causes of cancer-related death. Programmed cell death 1 (PD-1) and its ligand (PD-L1) are key physiologic suppressors of the cytotoxic immune reaction. Some authors advocate that PD-L1 expression may help in breast cancer prognosis.

Methods

We will conduct a systematic review of observational or interventional studies evaluating the prognostic ability of PD-L1 expression levels in predicting positive clinical outcomes in Human Breast Cancer. A sensitive search strategy will be employed in MEDLINE, EMBASE, LILACS, The Grey Literature Report, OpenGrey, OAIster, and Cochrane CENTRAL. Two reviewers will independently screen all identified references for eligibility and extr

SUBMITTER: Litvin IE 

PROVIDER: S-EPMC7098137 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature