Proenkephalin A Adds No Incremental Prognostic Value After Acute Ischemic Stroke.

ABSTRACT:

Objective

The aim of this study was to confirm previous observations that proenkephalin A (PENK-A) may serve as prognostic marker in the setting of acute ischemic stroke in a large stroke cohort.

Methods

The plasma concentration of PENK-A was measured within 72 hours of symptom onset in 320 consecutively enrolled patients with stroke. The primary outcome measures were unfavorable functional outcome (modified Rankin Scale score 0-2 vs 3-6) and mortality within 90 days. Logistic and cox proportional regression analyses were fitted to estimate odds ratios (ORs), hazard ratios (HRs) and 95% confidence intervals (CIs), respectively, for the association between PENK-A and the primary outcome measures.

Results

After adjusting for demographic and vascular risk factors, PENK-A

SUBMITTER: Gruber P 

PROVIDER: S-EPMC7098249 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature