Bioelution, Bioavailability, and Toxicity of Cobalt Compounds Correlate.

ABSTRACT: Based on the wide use of cobalt substances in a range of important technologies, it has become important to predict the toxicological properties of new or lesser-studied substances as accurately as possible. We studied a group of 6 cobalt substances with inorganic ligands, which were tested for their bioaccessibility (surrogate measure of bioavailability) through in vitro bioelution in simulated gastric and intestinal fluids. Representatives of the group also underwent in vivo blood kinetics and mass balance tests, and both oral acute and repeated dose toxicity (RDT) testing. We were able to show a good correlation between high in vitro bioaccessibility with high in vivo bioavailability and subsequent high in vivo toxicity; consequently, low in vitro bioaccessibility correlated well with l

SUBMITTER: Danzeisen R 

PROVIDER: S-EPMC7098370 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature