Longitudinal analyses of cerebrospinal fluid α-Synuclein in prodromal and early Parkinson's disease.

ABSTRACT:

Background

Aggregation of α-synuclein is central to the pathophysiology of PD. Biomarkers related to α-synuclein may be informative for PD diagnosis/progression.

Objectives

To analyze α-synuclein in CSF in drug-naïve PD, healthy controls, and prodromal PD in the Parkinson's Progression Markers Initiative.

Methods

Over up to 36-month follow-up, CSF total α-synuclein and its association with MDS-UPDRS motor scores, cognitive assessments, and dopamine transporter imaging were assessed.

Results

The inception cohort included PD (n = 376; age [mean {standard deviation} years]: 61.7 [9.62]), healthy controls (n = 173; age, 60.9 [11.3]), hyposmics (n = 16; age, 68.3 [6.15]), and idiopathic rapid eye movement sleep behavior disorder (n = 32; age, 69.3 [4.83]). Baseline

SUBMITTER: Mollenhauer B 

PROVIDER: S-EPMC7098385 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature