Impact of etonogestrel implant use on T-cell and cytokine profiles in the female genital tract and blood.

ABSTRACT:

Background

While prior epidemiologic studies have suggested that injectable progestin-based contraceptive depot medroxyprogesterone acetate (DMPA) use may increase a woman's risk of acquiring HIV, recent data have suggested that DMPA users may be at a similar risk for HIV acquisition as users of the copper intrauterine device and levonorgestrel implant. Use of the etonogestrel Implant (Eng-Implant) is increasing but there are currently no studies evaluating its effect on HIV acquisition risk.

Objective

Evaluate the potential effect of the Eng-Implant use on HIV acquisition risk by analyzing HIV target cells and cytokine profiles in the lower genital tract and blood of adult premenopausal HIV-negative women using the Eng-Implant.

Methods

We prospectively obtained paire

SUBMITTER: Haddad LB 

PROVIDER: S-EPMC7098611 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature