Cell cycle transcriptomics of Capsaspora provides insights into the evolution of cyclin-CDK machinery.

ABSTRACT: Progression through the cell cycle in eukaryotes is regulated on multiple levels. The main driver of the cell cycle progression is the periodic activity of cyclin-dependent kinase (CDK) complexes. In parallel, transcription during the cell cycle is regulated by a transcriptional program that ensures the just-in-time gene expression. Many core cell cycle regulators are widely conserved in eukaryotes, among them cyclins and CDKs; however, periodic transcriptional programs are divergent between distantly related species. In addition, many otherwise conserved cell cycle regulators have been lost and independently evolved in yeast, a widely used model organism for cell cycle research. For a better understanding of the evolution of the cell cycle regulation in opisthokonts, we investigated the t

SUBMITTER: Perez-Posada A 

PROVIDER: S-EPMC7098662 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature