Ontology highlight
ABSTRACT:
SUBMITTER: Easterhoff D
PROVIDER: S-EPMC7098725 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Easterhoff David D Pollara Justin J Luo Kan K Janus Benjamin B Gohain Neelakshi N Williams LaTonya D LD Tay Matthew Zirui MZ Monroe Anthony A Peachman Kristina K Choe Misook M Min Susie S Lusso Paolo P Zhang Peng P Go Eden P EP Desaire Heather H Bonsignori Mattia M Hwang Kwan-Ki KK Beck Charles C Kakalis Matina M O'Connell Robert J RJ Vasan Sandhya S Kim Jerome H JH Michael Nelson L NL Excler Jean-Louis JL Robb Merlin L ML Rerks-Ngarm Supachai S Kaewkungwal Jaranit J Pitisuttithum Punnee P Nitayaphan Sorachai S Sinangil Faruk F Tartaglia James J Phogat Sanjay S Wiehe Kevin K Saunders Kevin O KO Montefiori David C DC Tomaras Georgia D GD Moody M Anthony MA Arthos James J Rao Mangala M Joyce M Gordon MG Ofek Gilad G Ferrari Guido G Haynes Barton F BF
JCI insight 20200130 2
In the RV144 HIV-1 phase III trial, vaccine efficacy directly correlated with the magnitude of the variable region 2-specific (V2-specific) IgG antibody response, and in the presence of low plasma IgA levels, with the magnitude of plasma antibody-dependent cellular cytotoxicity. Reenrollment of RV144 vaccinees in the RV305 trial offered the opportunity to define the function, maturation, and persistence of vaccine-induced V2-specific and other mAb responses after boosting. We show that the RV144 ...[more]