Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis.

ABSTRACT: Acute kidney injury (AKI) and chronic kidney diseases are associated with high mortality and morbidity. Although the underlying mechanisms determining the transition from acute to chronic injury are not completely understood, immune-mediated processes are critical in renal injury. We have performed a comparison of 2 mouse models leading to either kidney regeneration or fibrosis. Using global gene expression profiling we could identify immune-related pathways accounting for the majority of the observed transcriptional changes during fibrosis. Unbiased examination of the immune cell composition, using single-cell RNA sequencing, revealed major changes in tissue-resident macrophages and T cells. Following injury, there was a marked increase in tissue-resident IL-33R+ and IL-2Ra+ regulatory T

SUBMITTER: do Valle Duraes F 

PROVIDER: S-EPMC7098794 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature