Synthesis of mono- and dimethoxylated polychlorinated biphenyl derivatives starting from fluoroarene derivatives.

ABSTRACT: Polychlorinated biphenyls (PCBs) are environmental pollutants implicated in a variety of adverse health effects, including cancer and noncancer diseases in animals and humans. PCBs are metabolized to hydroxylated compounds, and some of these PCB metabolites are more toxic than the parent PCBs. Unfortunately, most PCB metabolites needed for toxicological studies are not available from commercial sources. Moreover, it is challenging to synthesize PCB metabolites because starting materials with suitable substitution patterns are not readily available. Here, we report the novel synthesis of a variety of mono- and dimethoxyarene derivatives from commercially available fluoroarenes via nucleophilic aromatic substitution with sodium methoxide. This reaction provided good to excellent yields of th

SUBMITTER: Dhakal R 

PROVIDER: S-EPMC7098850 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature