Validation of simple measures of aortic distensibility based on standard 4-chamber cine CMR: a new approach for clinical studies.

ABSTRACT:

Objective

Aortic distensibility (AD) represents a well-established parameter of aortic stiffness. It remains unclear, however, whether AD can be obtained with high reproducibility in standard 4-chamber cine CMR images of the descending aorta. This study investigated the intra- and inter-observer agreement of AD based on different angles of the aorta and provided a sample size calculation of AD for future trials.

Methods

Thirty-one patients underwent CMR. Angulation of the descending aorta was performed to obtain strictly transversal and orthogonal cross-sectional aortic areas. AD was obtained both area and diameter based.

Results

For area-based values, inter-observer agreement was highest for 4-chamber AD (ICC 0.97; 95% CI 0.93-99), followed by orthogonal AD (ICC 0.96

SUBMITTER: Stoiber L 

PROVIDER: S-EPMC7098938 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature