Mucosal Microbiome Profiles Polygenic Irritable Bowel Syndrome in Mestizo Individuals.

ABSTRACT: Irritable bowel syndrome (IBS) is the most frequent functional gastrointestinal disorder, worldwide, with a high prevalence among Mestizo Latin Americans. Because several inflammatory disorders appear to affect this population, a further understanding of host genomic background variants, in conjunction with colonic mucosa dysbiosis, is necessary to determine IBS physiopathology and the effects of environmental pressures. Using a simple polygenic model, host single nucleotide polymorphisms (SNPs) and the taxonomic compositions of microbiota were compared between IBS patients and healthy subjects. As proof of concept, five IBS-Rome III patients and five healthy controls (HCs) were systematically studied. The human and bacterial intestinal metagenome of each subject was taxonomically annotate

SUBMITTER: Arredondo-Hernandez R 

PROVIDER: S-EPMC7098960 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature