Dentate Gyrus Volume Mediates the Effect of Fornix Microstructure on Memory Formation in Older Adults.

ABSTRACT: Age-related deterioration in white and gray matter is linked to cognitive deficits. Reduced microstructure of the fornix, the major efferent pathway of the hippocampus, and volume of the dentate gyrus (DG), may cause age-associated memory decline. However, the linkage between these anatomical determinants and memory retrieval in healthy aging are poorly understood. In 30 older adults, we acquired diffusion tensor and T1-weighted images for individual deterministic tractography and volume estimation. A memory task, administered outside of the scanner to assess retrieval of learned associations, required discrimination of previously acquired picture-word pairs. The results showed that fornix fractional anisotropy (FA) and left DG volumes were related to successful retrieval. These brain-beha

SUBMITTER: Hayek D 

PROVIDER: S-EPMC7098987 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature